Article

TNER: A Novel Background Error Suppression Method for Mutation Detection in Circulating Tumor DNA

2017-11-05

Abstract excerpt

The use of ultra-deep, next generation sequencing of circulating tumor DNA (ctDNA) holds great promise for early detection of cancer as well as a tool for monitoring disease progression and therapeutic responses. However, the low abundance of ctDNA in the bloodstream coupled with technical errors introduced during library construction and sequencing complicates mutation detection. To achieve high accuracy of varia...

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Literature Corpus work: 0e2e4a7e-36d7-53b1-ba11-ce38413a47af
DOI: 10.1101/214379

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