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Error Characterization and Statistical Modeling Improves Circulating Tumor DNA Detection by Droplet Digital PCR.

Clinical chemistry - 18 May 2022

Henriksen Tenna V, Drue Simon O, Frydendahl Amanda, Demuth Christina, Rasmussen Mads H, Reinert Thomas, Pedersen Jakob S, Andersen Claus L

Abstract excerpt

BACKGROUND: Droplet digital PCR (ddPCR) is a widely used and sensitive application for circulating tumor DNA (ctDNA) detection. As ctDNA is often found in low abundance, methods to separate low-signal readouts from noise are necessary. We aimed to characterize the ddPCR-generated noise and, informed by this, create a sensitive and specific ctDNA caller. METHODS: We built 2 novel complimentary ctDNA calling...

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PMID: 35030248
DOI: 10.1093/clinchem/hvab274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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