Article

BayVarC: an ultra-sensitive ctDNA variant caller using Bayesian approach

2024-02-07

Abstract excerpt

In liquid biopsy, it is critical to detect variants of allele frequencies as low as 0.1% or even lower, especially when used to monitor secondary resistant mutations and minimal residual disease. Despite the efforts on improving experimental design, it remains challenging to distinguish low-frequency variants from technical noises in the downstream bioinformatic analysis. Here, we introduce BayVarC, a novel varian...

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Literature Corpus work: bf03c7cf-370b-56a7-a15e-90d117eae172
DOI: 10.1101/2024.02.03.578772

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