Article

A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA

2020-02-10

Abstract excerpt

<h4>Background: </h4> Hybrid capture-based next-generation sequencing of DNA has been widely applied in the detection of circulating tumor DNA (ctDNA). Various methods have been proposed for ctDNA detection, but low-allelic-fraction (AF) variants are still a great challenge. In addition, no panel-wide calling algorithm is available, which hiders the full usage of ctDNA based ‘liquid biopsy’. Thus, we developed the...

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Literature Corpus work: f3ebc140-bcfd-5959-98e1-a4e458b9d4c5
DOI: 10.21203/rs.2.16704/v3

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