Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERASE-Seq: Leveraging replicate measurements to enhance ultralow frequency variant detection in NGS data.

PloS one - 1 Jan 2018

Kamps-Hughes Nick, McUsic Andrew, Kurihara Laurie, Harkins Timothy T, Pal Prithwish, Ray Claire, Ionescu-Zanetti Cristian

Abstract excerpt

The accurate detection of ultralow allele frequency variants in DNA samples is of interest in both research and medical settings, particularly in liquid biopsies where cancer mutational status is monitored from circulating DNA. Next-generation sequencing (NGS) technologies employing molecular barcoding have shown promise but significant sensitivity and specificity improvements are still needed to detect mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Barcoding, Taxonomic

Share to Gene Frequency

Share to Gene Library

Share to High-Throughput Nucleotide Sequencing

Share to INDEL Mutation

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 29630678
DOI: 10.1371/journal.pone.0195272
PMCID: PMC5890993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERASE-Seq: Leveraging replicate measurements to enhance ultralow frequency variant detection in NGS data.PMID 29630678Read ↗

Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling.Semantic proximity Read ↗

RareVar: A Framework for Detecting Low-Frequency Single-Nucleotide Variants.Semantic proximity Read ↗

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.Semantic proximity Read ↗

ABEMUS: platform-specific and data-informed detection of somatic SNVs in cfDNA.Semantic proximity Read ↗

Targeted sequencing of both DNA strands barcoded and captured individually by RNA probes to identify genome-wide ultra-rare mutations.Semantic proximity Read ↗

Comprehensive benchmarking of methods for mutation calling in circulating tumor DNA.Semantic proximity Read ↗

Comprehensive benchmarking of methods for mutation calling in circulating tumor DNASemantic proximity Read ↗

Next-generation sequencing methodologies to detect low-frequency mutations: "Catch me if you can".Semantic proximity Read ↗

Enhanced Error Suppression for Accurate Detection of Low-Frequency Variants.Semantic proximity Read ↗

Targeted error-suppressed quantification of circulating tumor DNA using semi-degenerate barcoded adapters and biotinylated baitsSemantic proximity Read ↗

Integrated RNA and DNA sequencing improves mutation detection in low purity tumorsSemantic proximity Read ↗

Quantitative Optimization of Sensitivity and Specificity in Targeted and Whole-Exome Sequencing Using Reference-Standard DNA MixturesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.