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Article

Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations.

Neurobiology of disease - 1 May 2009

Larimore Jennifer L, Chapleau Christopher A, Kudo Shinichi, Theibert Anne, Percy Alan K, Pozzo-Miller Lucas

Abstract excerpt

The expression of the methylated DNA-binding protein MeCP2 increases during neuronal development, which suggests that this epigenetic factor is crucial for neuronal terminal differentiation. We evaluated dendritic and axonal development in embryonic day-18 hippocampal neurons in culture by measuring total length and counting branch point numbers at 4 days in vitro, well before synapse formation. Pyramidal neurons...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19217433
DOI: 10.1016/j.nbd.2008.12.011
PMCID: PMC2726722

Genes

MECP2
BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations.PMID 19217433Read ↗

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