The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

Abstract excerpt

Mutations in the MECP2 gene cause Rett syndrome (RTT). Bdnf is a MeCP2 target gene; however, its role in RTT pathogenesis is unknown. We examined Bdnf conditional mutant mice for RTT-relevant pathologies and observed that loss of BDNF caused smaller brain size, smaller CA2 neurons, smaller glomerulus size, and a characteristic hindlimb-clasping phenotype. BDNF protein level was reduced in Mecp2 mutant mice, and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Action Potentials
• Share to Brain-Derived Neurotrophic Factor
• Share to Electric Stimulation