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Article

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations.

Neurobiology of disease - 1 Aug 2009

Chapleau Christopher A, Calfa Gaston D, Lane Meredith C, Albertson Asher J, Larimore Jennifer L, Kudo Shinichi, Armstrong Dawna L, Percy Alan K, Pozzo-Miller Lucas

Abstract excerpt

Rett syndrome (RTT) is an X chromosome-linked neurodevelopmental disorder associated with the characteristic neuropathology of dendritic spines common in diseases presenting with mental retardation (MR). Here, we present the first quantitative analyses of dendritic spine density in postmortem brain tissue from female RTT individuals, which revealed that hippocampal CA1 pyramidal neurons have lower spine density...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19442733
DOI: 10.1016/j.nbd.2009.05.001
PMCID: PMC2722110

Genes

MECP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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