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Article

MmpR5 protein truncation and bedaquiline resistance in Mycobacterium tuberculosis isolates from South Africa: a genomic analysis.

The Lancet. Microbe - 1 Aug 2024

Roberts Leah W, Malone Kerri M, Hunt Martin, Joseph Lavania, Wintringer Penelope, Knaggs Jeff, Crook Derrick, Farhat Maha R, Iqbal Zamin, Omar Shaheed V

Abstract excerpt

BACKGROUND: The antibiotic bedaquiline is a key component of new WHO regimens for drug-resistant tuberculosis; however, predicting bedaquiline resistance from bacterial genotypes remains challenging. We aimed to understand the genetic mechanisms of bedaquiline resistance by analysing Mycobacterium tuberculosis isolates from South Africa. METHODS: For this genomic analysis, we conducted whole-genome sequencing of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38851206
DOI: 10.1016/S2666-5247(24)00053-3

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