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An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in <i>M. tuberculosis</i> using a reproducible algorithmic approach

2025-01-30

Abstract excerpt

Bedaquiline (BDQ) has only been approved for use for a little over a decade yet is a key drug for treating multi-drug resistant tuberculosis, however rising levels of resistance threaten to reduce its effectiveness. Catalogues of mutations associated with resistance to bedaquiline are key to detecting resistance genetically for either diagnosis or surveillance. At present building catalogues requires considerable...

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Identifiers and source

Literature Corpus work
78d66f71-60f6-51c9-be31-223439fe2a7f
DOI
10.1101/2025.01.30.635633
Open publication

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An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in <i>M. tuberculosis</i> using a reproducible algorithmic approachDOI 10.1101/2025.01.30.635633
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