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Article

An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in Mycobacterium tuberculosis using a reproducible algorithmic approach.

Microbial genomics - 1 Jun 2025

Adlard Dylan, Joseph Lavania, Webster Hermione, O'Reilly Ailva, Knaggs Jeffrey, Peto Tim E A, Crook Derrick W, Omar Shaheed V, Fowler Philip W

Abstract excerpt

Bedaquiline (BDQ) has only been approved for use for just over a decade and is a key drug for treating multidrug-resistant tuberculosis; however, rising levels of resistance threaten to reduce its effectiveness. Catalogues of mutations associated with resistance to BDQ are key to detecting resistance genetically for either diagnosis or surveillance. At present, building catalogues requires considerable expert...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40531177
DOI: 10.1099/mgen.0.001429
PMCID: PMC12177157

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