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Article

Analysis of genetic characteristics associated with reduced bedaquiline susceptibility in multidrug-resistant Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2024

Wang Shanshan, Xiao Xiao, Dong Shulan, Cao Jiayi, Wang Sainan, Xiong Haiyan, Li Xuliang, Shao Ge, Hu Yi, Shen Xin

Abstract excerpt

Bedaquiline (BDQ) has shown efficacy in shortening treatment duration and enhancing treatment success rates for multidrug-resistant tuberculosis (MDR-TB), thereby prompting widespread adoption. However, resistance to BDQ has emerged. This study aimed to identify genetic characteristics associated with decreased susceptibility to BDQ, using a public database to aid in the detection of resistant strains....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39504872
DOI: 10.1016/j.tube.2024.102572

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