Article

Targeting DNA Methylation Reactivates Type I Interferon Signalling in Bone-Metastatic Breast Cancer

2026-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Bone metastasis remains a major clinical challenge in advanced breast cancer. Downregulation of type I interferon signalling, a critical immunomodulatory pathway in anti-cancer immunity and disease progression, is a defining feature of this process. Here, we utilised an IFN-reporter system to perform unbiased epigenetic compound screens to identify agents that could restore type I IFN signalling...

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Literature Corpus work: 0e14fb6c-80c9-575c-a2a6-27af2fb62d60
DOI: 10.64898/2026.06.28.735052

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