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Article

Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases.

Cancer research communications - 1 Aug 2024

Gellert Julia, Agardy Dennis A, Kumar Swaminathan, Kourtesakis Alexandros, Boschert Tamara, Jähne Kristine, Breckwoldt Michael O, Bunse Lukas, Wick Wolfgang, Davies Michael A, Platten Michael, Bunse Theresa

Abstract excerpt

Type I interferons (IFN) are immune-stimulatory cytokines involved in antiviral and antitumor immune responses. They enhance the efficacy of immunogenic anticancer therapies such as radiotherapy by activating both innate and adaptive immune cells. Macrophages are one of the most abundant innate immune cells in the immune microenvironment of melanoma brain metastases (MBM) and can exert potent immune-suppressive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39056192
DOI: 10.1158/2767-9764.CRC-24-0024
PMCID: PMC11337092

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