Article

CHA1: A New Combinatorial Therapy That Reciprocally Regulates Wnt and JAK/STAT/Interferon Signaling to Re-program Breast Tumors and the Tumor-Resident Landscape

2022-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Triple negative breast cancers (TNBC) pose exceptional challenges with fatal brain metastases as a clear and unmet need. Immune checkpoint inhibitors (ICIs) are promising therapeutic strategies, but most TNBC are resistant, or “cold” tumors, due to lack of tumor-resident immune engagement. No FDA-approved therapies exist which promote a “cold-to-hot” transition or induce the important biomarker...

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Literature Corpus work: 4947eddf-ec57-567b-8d1e-5f5f55bd0a91
DOI: 10.1101/2022.03.25.485706

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