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Improved polygenic risk prediction for alzheimer's disease and related dementias using deep learning: age and APOE-stratified analysis.

Alzheimer's research & therapy - 12 Mar 2026

Mostafaei Shayan, Shemer Daniel Wikström, Mak Jonathan K L, Karlsson Ida K, Hägg Sara

Abstract excerpt

BACKGROUND: Alzheimer’s disease and related dementias (ADRD) are complex, polygenic conditions with substantial public health impact. Accurate genetic risk prediction may enable earlier identification and stratification of individuals at elevated risk. OBJECTIVE: To evaluate the predictive performance of polygenic risk scores (PRS) for ADRD using a Bayesian variational autoencoders approach and to assess the...

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PMID: 41821099
DOI: 10.1186/s13195-026-02011-w
PMCID: PMC13063846

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APOE

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