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Article

Macrophage heterogeneity in atherosclerosis: A matter of context.

European journal of immunology - 1 Jan 2024

Wieland Elias B, Kempen Laura Jap, Donners Marjo Mpc, Biessen Erik Al, Goossens Pieter

Abstract excerpt

During atherogenesis, plaque macrophages take up and process deposited lipids, trigger inflammation, and form necrotic cores. The traditional inflammatory/anti-inflammatory paradigm has proven insufficient in explaining their complex disease-driving mechanisms. Instead, we now appreciate that macrophages exhibit remarkable heterogeneity and functional specialization in various pathological contexts, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37943053
DOI: 10.1002/eji.202350464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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