Article
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context.
Cell metabolism - 2 Aug 2022
Goossens Pieter, Lu Chang, Cao Jianhua, Gijbels Marion J, Karel Joël M H, Wijnands Erwin, Claes Britt S R, Fazzi Gregorio E, Hendriks Tim F E, Wouters Kristiaan, Smirnov Evgueni, van Zandvoort Marc J M, Balluff Benjamin, Cuypers Eva, Donners Marjo M P C, Heeren Ron M A, Biessen Erik A L
Abstract excerpt
Cells often adopt different phenotypes, dictated by tissue-specific or local signals such as cell-cell and cell-matrix contacts or molecular micro-environment. This holds in extremis for macrophages with their high phenotypic plasticity. Their broad range of functions, some even opposing, reflects their heterogeneity, and a multitude of subsets has been described in different tissues and diseases. Such...
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