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Article

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

1 Oct 2021

Abstract excerpt

Astrocyte-derived cholesterol supports brain cells under physiological conditions. However, in demyelinating lesions, astrocytes downregulate cholesterol synthesis, and the cholesterol that is essential for remyelination has to originate from other cellular sources. Here, we show that repair following acute versus chronic demyelination involves distinct processes. In particular, in chronic myelin disease, when...

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PMID: 34706227
DOI: 10.1016/j.celrep.2021.109889

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