Article

Antibody-mediated inhibition of ADAMTS-7 reduces experimental atherosclerosis

2026-08-19

Abstract excerpt

<h4>Objective</h4> One of the strongest genetic associations with coronary artery disease (CAD) risk maps to the metalloproteinase ‘a disintegrin and metalloproteinase with thrombospondin motifs 7’ (ADAMTS-7) locus. The protein was shown to promote plaque formation and instability. We aimed to generate and evaluate an antibody-based strategy targeting ADAMTS-7 therapeutically to reduce atherosclerotic plaque form...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0da7872a-c855-5879-81e6-f65377a806e2
DOI: 10.64898/2026.08.11.744317

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antibody-mediated inhibition of ADAMTS-7 reduces experimental atherosclerosisDOI 10.64898/2026.08.11.744317Read

ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosisSemantic proximity Read

Knockout of Adamts7 , a Novel Coronary Artery Disease Locus in Humans, Reduces Atherosclerosis in MiceSemantic proximity Read

An αIIb β3 antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia.Semantic proximity Read

Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis.Semantic proximity Read

ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.Semantic proximity Read

Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe⁻/⁻ mice.Semantic proximity Read

Complete Prevention of Atherosclerosis in ApoE-Deficient Mice by Hepatic Human ApoE Gene Transfer With Adeno-Associated Virus Serotypes 7 and 8Semantic proximity Read

Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties.Semantic proximity Read

Germ-line genetic variation in the immunoglobulin heavy chain creates stroke susceptibility in the spontaneously hypertensive rat.Semantic proximity Read

Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis.Semantic proximity Read

In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for ImagingSemantic proximity Read

The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization.Semantic proximity Read