Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complete Prevention of Atherosclerosis in ApoE-Deficient Mice by Hepatic Human ApoE Gene Transfer With Adeno-Associated Virus Serotypes 7 and 8

9 Jun 2006

Abstract excerpt

OBJECTIVE: Using intravenous injection of adeno-associated viral (AAV) vectors based on novel serotypes 7 and 8, we examined whether liver-specific expression of human apolipoprotein E (apoE) in apoE-deficient mice would completely prevent atherosclerosis after 1 year of sustained expression. METHODS AND RESULTS: Chow-fed apoE-/- mice were injected via the tail vein with vectors based on AAV2 or novel serotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Lipoproteins and Cardiovascular Health
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16763161
DOI: 10.1161/01.atv.0000231520.26490.54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complete Prevention of Atherosclerosis in ApoE-Deficient Mice by Hepatic Human ApoE Gene Transfer With Adeno-Associated Virus Serotypes 7 and 8PMID 16763161Read ↗

Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice.Semantic proximity Read ↗

Gene therapy with novel adeno‐associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemiaSemantic proximity Read ↗

Biodistribution of AAV8 Vectors Expressing Human Low-Density Lipoprotein Receptor in a Mouse Model of Homozygous Familial HypercholesterolemiaSemantic proximity Read ↗

Adeno-Associated Virus Serotype 8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial HypercholesterolemiaSemantic proximity Read ↗

Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of AtherosclerosisSemantic proximity Read ↗

Gene therapy of apolipoprotein E–deficient mice using a novel macrophage-specific retroviral vectorSemantic proximity Read ↗

Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− miceSemantic proximity Read ↗

AAV gene therapy as a means to increase apolipoprotein (Apo) A-I and high-density lipoprotein-cholesterol levels: correction of murine ApoA-I deficiency.Semantic proximity Read ↗

Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent.Semantic proximity Read ↗

In Vivo AAV-CRISPR/Cas9–Mediated Gene Editing Ameliorates Atherosclerosis in Familial HypercholesterolemiaSemantic proximity Read ↗

Two Hepatic Enhancers, HCR.1 and HCR.2, Coordinate the Liver Expression of the Entire Human Apolipoprotein E/C-I/C-IV/C-II Gene ClusterSemantic proximity Read ↗

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein ESemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.