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Article

Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis.

Cardiovascular research - 1 Aug 2011

Dunér Pontus, To Fong, Beckmann Karsten, Björkbacka Harry, Fredrikson Gunilla Nordin, Nilsson Jan, Bengtsson Eva

Abstract excerpt

AIMS: Oxidation of low-density lipoprotein in the extracellular matrix of the arterial wall results in the formation of malondialdehyde (MDA) that modifies surrounding matrix proteins. This is associated with the activation of an immune response against modified extracellular matrix proteins present in atherosclerotic plaques. Clinical studies have revealed an inverse association between antibodies to...

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Identifiers

PMID: 21493703
DOI: 10.1093/cvr/cvr101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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