Article
Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013
Khanicheh Elham, Qi Yue, Xie Aris, Mitterhuber Martina, Xu Lifen, Mochizuki Michika, Daali Youssef, Jaquet Vincent, Krause Karl-Heinz, Ruggeri Zaverio M, Kuster Gabriela M, Lindner Jonathan R, Kaufmann Beat A
Abstract excerpt
OBJECTIVE: Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation APPROACH AND RESULTS:...
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