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Article

The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization.

Journal of molecular biology - 1 Oct 2004

Hantgan Roy R, Stahle Mary C, Connor John H, Lyles Douglas S, Horita David A, Rocco Mattia, Nagaswami Chandrasekaran, Weisel John W, McLane Mary Ann

Abstract excerpt

We have employed echistatin, a 5.4 kDa snake venom disintegrin, as a model protein to investigate the paradox that small ligand-mimetics can bind to the resting alphaIIbbeta3 integrin while adhesive macromolecules cannot. We characterized the interactions between purified human alphaIIbbeta3 and two recombinant echistatin variants: rEch (1-49) M28L, chosen for its selectivity toward beta3-integrins, and rEch...

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Identifiers

PMID: 15364586
DOI: 10.1016/j.jmb.2004.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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