Article

Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progression

2022-01-28

Abstract excerpt

Multimodal single cell sequencing is a powerful tool for interrogating cell-specific changes in transcription and chromatin accessibility. We performed single nucleus RNA (snRNA-seq) and assay for transposase accessible chromatin sequencing (snATAC-seq) on human kidney cortex from donors with and without diabetic kidney disease (DKD) to identify altered signaling pathways and transcription factors associated with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d97f586-fb96-5477-8d51-ca066f22b2c1
DOI: 10.1101/2022.01.28.478204

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progressionDOI 10.1101/2022.01.28.478204Read

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidneySemantic proximity Read

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progressionSemantic proximity Read

The single-cell transcriptomic landscape of early human diabetic nephropathySemantic proximity Read

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.Semantic proximity Read

The Single Cell Transcriptomic Landscape of Early Human Diabetic NephropathySemantic proximity Read

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney functionSemantic proximity Read

Mapping kidney trait heritability to individual cells reveals disease-specific remodeling of genetic risk architectureSemantic proximity Read

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysisSemantic proximity Read

A Human Glomerular Disease Atlas defines the APOL1-JAK-STAT feed forward loop in focal segmental glomerulosclerosisSemantic proximity Read

Cell Type-Specific and Diabetic Kidney Disease-Associated Expression of Long Non-Coding RNAs in Human KidneysSemantic proximity Read

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms.Semantic proximity Read

Single‐cell RNA ‐seq with spatial transcriptomics to create an atlas of human diabetic kidney diseaseSemantic proximity Read