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A Human Glomerular Disease Atlas defines the APOL1-JAK-STAT feed forward loop in focal segmental glomerulosclerosis

2025-09-14

Abstract excerpt

There are few approved treatments for glomerular diseases of the kidney. To map underlying transcriptional programs in the kidney driving rare glomerular diseases, single-nucleus RNA sequencing (snRNAseq) on kidney biopsies (N=120) from the Nephrotic Syndrome Study Network were integrated with snRNAseq and single-cell sequencing (scRNAseq) of reference kidney tissue (N=50) to create the Omnibus of CElls And Nuclei...

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Identifiers and source

Literature Corpus work
59a32e9c-d9bc-53ea-bcb1-e4675e98e002
DOI
10.1101/2025.09.12.25335572
Open publication

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A Human Glomerular Disease Atlas defines the APOL1-JAK-STAT feed forward loop in focal segmental glomerulosclerosisDOI 10.1101/2025.09.12.25335572
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