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Article

The single-cell transcriptomic landscape of early human diabetic nephropathy

10 Sept 2019

Abstract excerpt

Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium, but relatively little is known about accompanying cell-specific changes in gene expression. We performed unbiased single-nucleus RNA sequencing (snRNA-seq) on cryopreserved human diabetic kidney samples to generate 23,980 single-nucleus transcriptomes from 3 control and 3 early diabetic nephropathy samples. All major...

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PMID: 31506348
DOI: 10.1073/pnas.1908706116

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