Article

A Feedback Motif that Breaks the Fundamental Limit on Noise Suppression to Stabilize Fate

2017-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Diverse biological systems utilize gene-expression fluctuations (‘noise’) to drive lineage-commitment decisions 1-5 . However, once a commitment is made, noise becomes detrimental to reliable function 6,7 and the mechanisms enabling post-commitment noise suppression are unclear. We used time-lapse imaging and mathematical modeling, and found that, after a noise-driven event, human immunodefici...

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Literature Corpus work: cf0731a0-e1d2-5636-b90e-c2945e94486f
DOI: 10.1101/141390

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