Article

ALT in Pediatric High-Grade Gliomas Can Occur without <i>ATRX</i> Mutation and is Enriched in Patients with Pathogenic Germline MMR Variants

2022-08-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> To achieve replicative immortality, most cancers develop a telomere maintenance mechanism, such as reactivation of telomerase or alternative lengthening of telomeres (ALT). There are limited data on the prevalence and clinical significance of ALT in pediatric brain tumors, and ALT-directed therapy is not available. <h4>Methods</h4> We performed C-circle analysis (CCA) on 57...

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Literature Corpus work: 0d94edf8-d9e0-5c9f-bd88-ebb6b5d93e67
DOI: 10.1101/2022.08.05.502870

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