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Mechanisms of telomere maintenance and associated therapeutic vulnerabilities in malignant gliomas

29 Jan 2024

Abstract excerpt

A majority of cancers (~85%) activate the enzyme telomerase to maintain telomere length over multiple rounds of cellular division. Telomerase-negative cancers activate a distinct, telomerase-independent mechanism of telomere maintenance termed alternative lengthening of telomeres (ALT). ALT uses homologous recombination to maintain telomere length and exhibits features of break-induced DNA replication. In...

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Share to DNA Repair Mechanisms
Share to Glioma Diagnosis and Treatment
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38285162
DOI: 10.1093/neuonc/noae016

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