Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.

doi:10.1093/neuonc/noac278

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Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.

Neuro-oncology - 6 Jul 2023

Stundon Jennifer L, Ijaz Heba, Gaonkar Krutika S, Kaufman Rebecca S, Jin Run, Karras Anastasios, Vaksman Zalman, Kim Jung, Corbett Ryan J, Lueder Matthew R, Miller Daniel P, Guo Yiran, Santi Mariarita, Li Marilyn, Lopez Gonzalo, Storm Phillip B, Resnick Adam C, Waanders Angela J, MacFarland Suzanne P, Stewart Douglas R, Diskin Sharon J, Rokita Jo Lynne, Cole Kristina A

Abstract excerpt

BACKGROUND: To achieve replicative immortality, most cancers develop a telomere maintenance mechanism, such as reactivation of telomerase or alternative lengthening of telomeres (ALT). There are limited data on the prevalence and clinical significance of ALT in pediatric brain tumors, and ALT-directed therapy is not available. METHODS: We performed C-circle analysis (CCA) on 579 pediatric brain tumors that had...

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PMID: 36541551
DOI: 10.1093/neuonc/noac278
PMCID: PMC10326481

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ATRX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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