Article

Functional Assessment of ATRX Alterations Improves Glioma Diagnosis

2025-07-18

Abstract excerpt

<title>Abstract</title> <p> Loss of ATRX function, a diagnostic criterion of IDH-mutant astrocytoma, is closely associated with alternative lengthening of telomeres (ALT), a telomere maintenance mechanism (TMM). As immunohistochemical (IHC) assessment of ATRX is error-prone, sequencing has been integrated into clinical workflows. While frameshift and nonsense variants can be classified as loss-of-function (LOF)...

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Literature Corpus work: aaae8dc8-8d2d-50a4-9eb8-c39b335761fd
DOI: 10.21203/rs.3.rs-6974009/v1

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