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Article

Pediatric low-grade gliomas can be molecularly stratified for risk.

Acta neuropathologica - 1 Oct 2018

Yang Rui Ryan, Aibaidula Abudumijiti, Wang Wei-Wei, Chan Aden Ka-Yin, Shi Zhi-Feng, Zhang Zhen-Yu, Chan Danny Tat Ming, Poon Wai Sang, Liu Xian-Zhi, Li Wen-Cai, Zhang Rui-Qi, Li Yan-Xi, Chung Nellie Yuk-Fei, Chen Hong, Wu Jingsong, Zhou Liangfu, Li Kay Ka-Wai, Ng Ho-Keung

Abstract excerpt

Pediatric low-grade gliomas (PLGGs) consist of a number of entities with overlapping histological features. PLGGs have much better prognosis than the adult counterparts, but a significant proportion of PLGGs suffers from tumor progression and recurrence. It has been shown that pediatric and adult low-grade gliomas are molecularly distinct. Yet the clinical significance of some of newer biomarkers discovered by...

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Identifiers

PMID: 29948154
DOI: 10.1007/s00401-018-1874-3

Genes

BRAF
ATRX
MYB
TERT

Variants

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