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Article

Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Mar 2021

Minasi Simone, Baldi Caterina, Gianno Francesca, Antonelli Manila, Buccoliero Anna Maria, Pietsch Torsten, Massimino Maura, Buttarelli Francesca Romana

Abstract excerpt

PURPOSE: The maintenance of telomere length prevents cancer cell senescence and occurs via two mutually exclusive mechanisms: (a) reactivation of telomerase expression and (b) activation of alternative lengthening of telomeres (ALT). ALT is frequently related to alterations on ATRX, a chromatin-remodelling protein. Recent data have identified different molecular subgroups of paediatric high-grade glioma (pHGG)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33128602
DOI: 10.1007/s00381-020-04933-8
PMCID: PMC7875853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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