Article
Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors.
Acta neuropathologica - 1 Dec 2014
Mangerel Joshua, Price Aryeh, Castelo-Branco Pedro, Brzezinski Jack, Buczkowicz Pawel, Rakopoulos Patricia, Merino Diana, Baskin Berivan, Wasserman Jonathan, Mistry Matthew, Barszczyk Mark, Picard Daniel, Mack Stephen, Remke Marc, Starkman Hava, Elizabeth Cynthia, Zhang Cindy, Alon Noa, Lees Jodi, Andrulis Irene L, Wunder Jay S, Jabado Nada, Johnston Donna L, Rutka James T, Dirks Peter B, Bouffet Eric, Taylor Michael D, Huang Annie, Malkin David, Hawkins Cynthia, Tabori Uri
Abstract excerpt
Although telomeres are maintained in most cancers by telomerase activation, a subset of tumors utilize alternative lengthening of telomeres (ALT) to sustain self-renewal capacity. In order to study the prevalence and significance of ALT in childhood brain tumors we screened 517 pediatric brain tumors using the novel C-circle assay. We examined the association of ALT with alterations in genes found to segregate...
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