Article

Carriers of<i>LRRK2</i>pathogenic variants show a milder, anatomically distinct brain signature of Parkinson’s disease

2025-03-10

Abstract excerpt

LRRK2 gene variants are a major genetic risk factor for both familial and sporadic Parkinson’s disease (PD), opening an unattended window on the disease’s mechanisms and potential therapies. Investigating the influence of pathogenic variants in LRRK2 gene on brain structure is a crucial step toward enabling early diagnosis and personalized treatment. Yet, despite its significance, the ways in which LRRK2 genotype...

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Literature Corpus work: 0d8ccfc3-3085-55e6-af4d-d3504c78a720
DOI: 10.1101/2025.03.09.25323610

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