Article

Neuroanatomical correlates of polygenic risk for Parkinson’s Disease

2022-01-18

Abstract excerpt

Parkinson ‘s Disease (PD) is heritable, however how genetic risk confers vulnerability remains mostly unknown. Here we use genetic and neuroimaging measures from 20,000 healthy adults from the UK Biobank to show that PD polygenic risk score (PRS) is associated with cortical thinning in a pattern that resembles cortical atrophy seen in PD. Conversely, PD PRS is associated with a global increase in cortical surface...

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Literature Corpus work: f9d17445-3e6a-5606-9f66-d5c5468e4704
DOI: 10.1101/2022.01.17.22269262

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