Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease.

Annals of neurology - 1 Nov 2021

Das Sandhitsu R, Lyu Xueying, Duong Michael Tran, Xie Long, McCollum Lauren, de Flores Robin, DiCalogero Michael, Irwin David J, Dickerson Bradford C, Nasrallah Ilya M, Yushkevich Paul A, Wolk David A

Abstract excerpt

OBJECTIVE: Tau neurofibrillary tangles (T) are the primary driver of downstream neurodegeneration (N) and subsequent cognitive impairment in Alzheimer's disease (AD). However, there is substantial variability in the T-N relationship - manifested in higher or lower atrophy than expected for level of tau in a given brain region. The goal of this study was to determine if region-based quantitation of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Amyloid beta-Peptides

Share to Atrophy

Share to Cognitive Dysfunction

Share to Neurofibrillary Tangles

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34617306
DOI: 10.1002/ana.26233
PMCID: PMC8841129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease.PMID 34617306Read ↗

Medial temporal lobe Tau-Neurodegeneration <i>mismatch</i> from MRI and plasma biomarkers identifies vulnerable and resilient phenotypes with ADSemantic proximity Read ↗

Revealing Individual Neuroanatomical Heterogeneity in Alzheimer’s DiseaseSemantic proximity Read ↗

Multimodal axes reveal individualized amyloid-β, tau, and neurodegeneration coupling in aging and Alzheimer’s diseaseSemantic proximity Read ↗

Multimodal and longitudinal characterization of distinct tau and atrophy clusters in Alzheimer’s disease spectrumSemantic proximity Read ↗

Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulationSemantic proximity Read ↗

Clinical phenotypes of Alzheimer's disease: investigating atrophy patterns and their pathological correlates.Semantic proximity Read ↗

Neuronal Distribution of Tau Pathology, Microglial Gene Expression Trajectories, and Resilience to Alzheimer diseaseSemantic proximity Read ↗

A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer’s diseaseSemantic proximity Read ↗

Characterizing the spatiotemporal variability of Alzheimer’s disease pathologySemantic proximity Read ↗

Structural heterogeneity reveals distinct amyloidopathies in Alzheimer’s diseaseSemantic proximity Read ↗

Differential Brain Atrophy Patterns and Neurogenetic Profiles in Cognitively-Defined Alzheimer’s Disease SubgroupsSemantic proximity Read ↗

Tau-Clinical Mismatch Identifies Individuals with Co-Pathology and Predicts Clinical TrajectorySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.