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Article

Investigating causal relations between brain morphology and genetic risk variants in Parkinson's disease.

NeuroImage. Clinical - 1 Jan 2026

Dagasso Gabrielle, Vigneshwaran Vibujithan, Winder Anthony J, Souza Raissa, Ohara Erik Y, Wilms Matthias, Forkert Nils D

Abstract excerpt

Imaging genomics for Parkinson's disease (PD) research aims to integrate genetic and imaging biomarkers to explore how genetic alterations influence brain morphology and function. However, traditional methods have been largely correlative, limiting their utility. Recent advances in machine learning offer potential for exploring causal relationships, although these have not yet been applied to investigate genetic...

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Identifiers

PMID: 41519071
DOI: 10.1016/j.nicl.2025.103928
PMCID: PMC12816864

Genes

GBA1
SATB1

Variants

rs75548401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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