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Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson's Disease and Their First-Degree Unaffected Relatives.

Brain topography - 1 Nov 2018

Thaler Avner, Kliper Efrat, Maidan Inbal, Herman Talia, Rosenberg-Katz Keren, Bregman Noa, Gurevich Tanya, Shiner Tamara, Hausdorff Jeffrey M, Orr-Urtreger Avi, Giladi Nir, Mirelman Anat

Abstract excerpt

Cerebral atrophy has been detected in patients with Parkinson's disease (PD) both with and without dementia, however differentiation based on genetic status has thus far not yielded robust findings. We assessed cortical thickness and subcortical volumes in a cohort of PD patients and healthy controls carriers of the G2019S mutation in the LRRK2 gene and the common GBA mutations, in an attempt to determine whether...

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PMID: 29846835
DOI: 10.1007/s10548-018-0653-8

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