Characterizing the distinct neuroanatomical phenotypes, cognitive profiles, and transcriptomic signatures of brain structural subtypes in Parkinson's disease with mild cognitive impairment.

Abstract excerpt

BACKGROUND: Parkinson's disease with mild cognitive impairment (PD-MCI) shows notable heterogeneity in cognitive presentation and progression. Current diagnostic frameworks assume biological homogeneity. Identifying biologically defined subtypes using neuroimaging-based individual biomarkers, cognitive profiles, and molecular signatures can clarify disease heterogeneity and advance precision medicine approaches....

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