Article

Increased NLRP3 inflammasome activation and pyroptosis in multiple sclerosis patients with fingolimod treatment failure

2022-07-18

Abstract excerpt

<h4>Background: </h4> Inflammasomes are involved in the pathogenesis of different neuroimmune and neurodegenerative diseases, including multiple sclerosis (MS). In a previous study by our group, the nucleotide-binding oligomerization domain, leucine-rich repeat receptor and pyrin-domain containing 3 (NLRP3) inflammasome was reported to be associated with the response to interferon-beta in MS. Based on recent data...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d81c448-4151-50c8-b845-3aa7768db560
DOI: 10.21203/rs.3.rs-1831031/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased NLRP3 inflammasome activation and pyroptosis in multiple sclerosis patients with fingolimod treatment failureDOI 10.21203/rs.3.rs-1831031/v1Read

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis.Semantic proximity Read

Etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cellsSemantic proximity Read

A patent review of NLRP3 inhibitors to treat autoimmune diseasesSemantic proximity Read

Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseasesSemantic proximity Read

United Europeans for development of pharmacogenomics in multiple sclerosis network.Semantic proximity Read

Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosisSemantic proximity Read

Inflammasome Gene Polymorphisms (NLRP3 and NLRC4) and Vitamin D Status in Patients with Multiple Sclerosis.Semantic proximity Read

The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndromeSemantic proximity Read

Drug library screen identifies inhibitors of toxic astrogliosisSemantic proximity Read

Association of nod‐like receptor protein‐3 single nucleotide gene polymorphisms and expression with the susceptibility to relapsing–remitting multiple sclerosisSemantic proximity Read

The NLRP3 inhibitor MCC950 inhibits IL-1β production in PBMC from 19 patients with Cryopyrin-Associated Periodic Syndrome and in 2 patients with Schnitzler’s SyndromeSemantic proximity Read

Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma modelSemantic proximity Read