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The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome

22 May 2024

Abstract excerpt

Hyperinflammatory disease is associated with an aberrant immune response resulting in cytokine storm. One such instance of hyperinflammatory disease is known as macrophage activation syndrome (MAS). The pathology of MAS can be characterised by significantly elevated serum levels of interleukin-18 (IL-18) and interferon gamma (IFNγ). Given the role for IL-18 in MAS, we sought to establish the role of inflammasomes...

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PMID: 38775430
DOI: 10.1242/dmm.050762

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