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Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model

29 Apr 2020

Abstract excerpt

Lung inflammation due to sarcoidosis is characterized by a complex cascade of immunopathologic events, including leukocyte recruitment and granuloma formation. α-melanocyte stimulating hormone (α-MSH) is a melanocortin signaling peptide with anti-inflammatory properties. We aimed to evaluate the effects of α-MSH in a novel in vitro sarcoidosis model. An in vitro sarcoidosis-like granuloma model was developed by...

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PMID: 32350353
DOI: 10.1038/s41598-020-64305-9

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