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Article

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis.

Brain : a journal of neurology - 1 Mar 2015

Malhotra Sunny, Río Jordi, Urcelay Elena, Nurtdinov Ramil, Bustamante Marta F, Fernández Oscar, Oliver Begoña, Zettl Uwe, Brassat David, Killestein Joep, Lechner-Scott Jeannette, Drulovic Jelena, Chan Andrew, Martinelli-Boneschi Filippo, García-Merino Antonio, Montalban Xavier, Comabella Manuel

Abstract excerpt

Evidence exists for a potential modulation of inflammasome activity by interferon beta. Here, we investigated the roles of inflammasomes [absent in melanoma 2 (AIM2); NLR family, CARD domain containing 4 (NLRC4); NLR family, pyrin domain containing 1 and 3 (NLRP1 and NLRP3)] and related cytokines (IL1B, IL10, IL18) in the response to interferon beta in patients with relapsing-remitting multiple sclerosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25586466
DOI: 10.1093/brain/awu388
PMCID: PMC4408432

Genes

NLRP3
AIM2
NLRC4
NLRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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