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Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis

3 Feb 2017

Abstract excerpt

Multiple sclerosis is a demyelinating disease affecting the central nervous system. T cells are known to contribute to this immune-mediated condition. Fingolimod modulates sphingosine-1-phosphate receptors, thereby preventing the egress of lymphocytes, especially CCR7-expressing CD8+ and CD4+ T cells, from lymphoid tissues. Using Affymetrix Human Transcriptome Arrays (HTA 2.0), we performed a transcriptome...

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PMID: 28155899
DOI: 10.1038/srep42087

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