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Article

Inflammasome Gene Polymorphisms (NLRP3 and NLRC4) and Vitamin D Status in Patients with Multiple Sclerosis.

International journal of molecular sciences - 22 May 2026

Scazzone Concetta, Agnello Luisa, Gambino Caterina Maria, Bellia Chiara, Salemi Giuseppe, Masucci Anna, Novara Sabrina, Ciaccio Marcello

Abstract excerpt

Multiple Sclerosis (MS) is a neuroinflammatory disorder in which genetic and environmental factors contribute to disease onset. Evidence implicates the inflammasome pathway in MS pathophysiology. However, the interaction between inflammasome-related genetic variants and 25-OH-vitamin D3 (25(OH)D3) levels remains unclear. 105 MS patients and 109 healthy controls were enrolled. Genotyping of NLRP3 (rs10754558,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42278212
DOI: 10.3390/ijms27114681
PMCID: PMC13256696

Genes

NLRP3
NLRC4

Provenance

PubMed metadata and Literature Corpus relationships.

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