TLR3 Activation of Microglia-Containing Cerebral Organoid Induces Antiviral Factors against HIV-1 Infection

Abstract excerpt

Human induced pluripotent stem cell (iPSC)-derived cerebral organoids have been increasingly used as a brain model for studying various neurological disorders and neurotropic virus infections, including HIV-1. However, it is unclear whether iPSC-derived cerebral organoids possess functional innate antiviral immunity against HIV-1. In this study, we examined Toll-Like Receptor 3 (TLR3) activation and its role in th...

Topics

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• Cytomegalovirus and herpesvirus research
• Herpesvirus Infections and Treatments
• HIV/AIDS Research and Interventions
• HIV-related health complications and treatments
• HIV Research and Treatment
• Neuroinflammation and Neurodegeneration Mechanisms
• Primate Behavior and Ecology
• RNA regulation and disease

Identifiers and source

Literature Corpus work

0d68c0b3-b82e-507d-ac2e-1e2d12a59300

DOI

10.64898/2025.12.17.695025