Article
Runx2 drives Schwann cells repair phenotype switch through chromatin remodeling and Sox2 activation after nerve injury.
Molecular medicine (Cambridge, Mass.) - 21 Mar 2025
He Bo, Su Shouwen, Zhang Zeyu, Lin Zhongpei, Qiu Qinglin, Yang Yan, Wen Xiaoyue, Zhu Zhaowei
Abstract excerpt
BACKGROUND: The states of Schwann cells undergo significant shifts during nerve regeneration. Previous studies have shown the expression of Runx2 is locally upregulated within the affected areas. However, the regulatory mechanisms underlying its epigenetic control remain unclear. METHODS: To investigate the epigenetic mechanisms through which Runx2 influences the phenotypic transition of repair Schwann cells....
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- Animals
- Schwann Cells
- Core Binding Factor Alpha 1 Subunit
- Rats
- SOXB1 Transcription Factors
- Nerve Regeneration