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Article

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3

23 May 2008

Abstract excerpt

BACKGROUND: The transcription factor STAT3 is a downstream target of the LIF signalling cascade. LIF signalling or activation is sufficient to maintain embryonic stem (ES) cells in an undifferentiated and pluripotent state. To further investigate the importance of STAT3 in the establishment of ES cells we have in a first step derived stable pluripotent embryonic stem cells from transgenic FVB mice expressing a...

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PMID: 18500982
DOI: 10.1186/1471-213x-8-57

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